In 2022, 10 new landmarks and one new historic district were designated in DC. Of these 11 new designations, six were sponsored or co-sponsored by DCPL! In February, the Buzzard Point Power Plant in Southwest, which was nominated by DCPL in 2016, was added to the DC Inventory of Historic Sites. In March, the stunning Nixon-Mounsey House was historically designated by HPRB. This Streamline Moderne style home in The Palisades was nominated by both DCPL and the homeowners, and it has since been added to the National Register of Historic Places. Also in March, the National Geographic Society Headquarters, located along M Street NW between 16th and 17th streets, was designated. At the hearing, HPRB accepted nominations from both DCPL and the National Geographic Society. DCPL's nomination focused on the remarkable Edward Durell Stone-designed building at 17th and M streets NW.

In May, the beloved Uptown Theater was designated. Although the theater had always been a contributing property within the Cleveland Park Historic District, it was not individually landmarked. This nomination was co-sponsored by both DCPL and the Cleveland Park Historical Society, and added to the National Register in December. In July, the National Association for the Relief of Destitute Colored Women and Children (Merriweather Home for Children) in Pleasant Plains was designated and, thus, saved from demolition. The building has since been added to the National Register. This nomination received an incredible amount of community support, as the site has long served residents of the surrounding neighborhoods. Also in July, the Schlitz Brewing Company Washington Branch / National Geographic Society Warehouse in Eckington was designated.

Throughout the year, these other properties were officially added to the DC Inventory: Seafarers Yacht Club (February), St. Joseph's Seminary (May), Founding Church of Scientology (June), National Training School for Women and Girls Historic District (October, final name pending), and Buchanan School Plaza/Peter Bug Shoe Academy (November). Also, two amendments for existing historic sites were approved by HPRB: Lafayette Square Historic District (September) and Washington City Canal Lockkeeper’s House (October).